ESPN 50th Annual Meeting

ESPN 2017


 
Trends in histopathological pattern among children with idiopathic nephrotic syndrome.
MAHMOUD EL-KERSH 1 HANAN FATHY 1 SARA ABUL SEOUD 1

1- FACULTY OF MEDICINE, ALEXANDRIA UNIVERSITY, EGYPT
 
Introduction:

 Recent studies found that there is increasing incidence of focal segmental glomerulosclerosis (FSGS) in children with idiopathic nephrotic syndrome (INS). We aimed at study of the histopathological pattern in children attending the Alexandria University Childrens Hospital. 

Material and methods:

Review of the files of 356 child with INS from the year 1992 to 2001 (group A) and comparing their data with those of 185 child from the year 2010 to 2014 (group B).  

Results:

 The mean age was 9.72±4.7 years and age at onset of the disease was 4.97±2.97 years for group A, while the mean age was 7.35±3.02 years and age at onset of the disease was 4.46±2.57 years for group B. Renal biopsy was performed in 63 patients in group A and 34 patients in group B because of steroid resistance or frequent relapse. Steroid responsive patients were considered to have minimal change nephrotic syndrome (MCNS). The incidence regarding mesangioproliferative glomerulonephritis (MesPGN), FSGS, Membranoproliferative glomerulonephritis (MPGN) and MCNS was 7.8%, 2.3%, 4.3% and 77.9% respectively in group A, while it was 10.1%, 6.8%, 3.4% and 79.7% respectively in group B. 

Conclusions:

 MCNS is still the predominant histopathological type. Although there was almost a threefold increase in the incidence of FSGS, MesPGN was the next coming histopathological type after MCNS.