ESPN 50th Annual Meeting

ESPN 2017


 
THE STAGES OF MORPHOLOGICAL CHANGES AT THE DEVELOPMENT OF NEPHROSCLEROSIS IN CHILDREN WITH OBSTRUCTIVE UROPATHY
ALEXANDRA KRUTOVA 1 VALENTINA LUCHANINOVA 2 ELENA MELNIKOVA 1 OLGA SEMESHINA 1 OXANA PERELOMOVA 3

1- "CHILDRENS REGIONAL CLINICAL HOSPITAL №1", VLADIVOSTOK, RUSSIA
2- NORTH-WEST STATE MEDICAL UNIVERSITY BY I.I. MECHNIKOV OF THE MINISTRY OF PUBLIC HEALTH RUSSIAN FEDERATION, ST. PETERSBURG, RUSSIA
3- PACIFIC STATE MEDICAL UNIVERSITY, VLADIVOSTOK, RUSSIA
 
Introduction:

 Despite the variety of pathogenetic mechanisms of damage of renal tissue, the consequences of all these processes lead up to the formation of nephrosclerosis with the development of renal failure. The purpose of the study is to develop an algorithm for early diagnosis of the extent of kidney damage based on data of correlation analysis of morphometric changes.

Material and methods:

 Material for the research included 29 specimens of renal tissue of children. 17 of them were obtained using in vivo biopsies and 12 autopsies from children suffering from kidney diseases at the age from 3 months to 16 years. All the children suffered from obstructive uropathy, the duration of illness in 70% of them were more than a year. At the statistical processing of the received materials the package of applied programs Statistica 10.0 in Windows 2010 are used. To study the correlation between pairs of symptoms using the Pearsons correlation (r) was performed.

Results:

 When analyzing the results of a study of the morphological samples, the criteria for changing the tissue structure of a particular area are determined, reflecting the degree and severity of the renal parenchyma lesions. Early indicators of renal parenchyma damage include: the presence of degeneration and/or tubular atrophy, lymphohistiocytic infiltration, angiomatosis of blood vessels. To more pronounced changes in the kidney tissue, to the early changes included: thinning of the parenchyma and thickening of the blood vessels walls. And the most severe pathological changes is the progression of atrophy, sclerosis of tubules, glomeruli, renal vessels with impaired cortical and medulla differentiation of the kidney substance. Statistical analysis are revealed correlations of different strength and direction of the morphometric criteria of nephrosclerosis with the degree of development of degenerative changes of glomeruli, tubules, vessels with outcome in sclerosis. Comparing the data of the statistical study of correlation and morphometric changes, there are 3 successive stages of development of nephrosclerosis.

Conclusions:

 Statistics in medicine is one of the tools for the evaluation of experimental data and clinical observations. On the basis of statistical analysis the classification of nephrosclerosis stages are proposed with the indication the extent and depth of the renal lesions at the histomorphological study. The statistically significant criteria nephrosclerotic changes in the kidneys are allocated.