ESPN 50th Annual Meeting

ESPN 2017


 
INTERRELATION OF ERYTHROPOIETIN (EPO), HYPOXIA INDUCIBLE FACTOR-1α (HIF-1α) AND THE GLOMERULAR FILTRATION RATE (GFR) BY ANEMIA IN CHILDREN WITH CHRONIC KIDNEY DISEASE (CKD)
ELENA LYSOVA 1 NADEZHDA SAVENKOVA 1

1- SAINT-PETERSBURG STATE PEDIATRIC MEDICAL UNIVERSITY, RUSSIAN FEDERATION
 
Introduction:

To evaluate the interrelation of EPO, HIF-1α and the GFR in children with anemia in  CKD.

Material and methods:

We analyzed levels of EPO and HIF-1α in 80 patients with anemia in CKD: 39 boys (48, 75 %) and 41 girls (51, 25%). Three groups of patients: I (32) predialysis without therapy, II (18) predialysis with therapy, III (30) dialysis (21-HD, 9-PD).

Results:

80 patients with anemia in CKD32 patients (I Group) with CKD had mean GFR 42,89±25,2 ml/min/1,73 m²; Hb level  103,2 ±8,5g/dl, EPO level was 28,1±20,6 mIU/ml; HIF-1α levels 0,163±0,4pg/ml. 18 patients (II Group) had mean GFR 31,5±26,4 ml/min/1,73 m²; Hb level  100 ±10g/dl, EPO level was 118±25,4 mIU/ml; HIF-1α levels 0,12±0,1pg/ml. 30 patients (III Group) had mean GFR 13,1±6,2 ml/min/1,73 m²; Hb level 85 ±14,4g/dl, EPO level was 34,3±43,8 mIU/ml; HIF-1α levels 0,09±0,07pg/ml. EPO level in children II Group was higher, compared with I and III Group (p <0,05). HIF-1α correlated with GFR by18 patients II Group (R=0,589, p<0,05), by 32 patients I group (R=0, 42), by 30 patients III group (R=0,087).

Conclusions:

We identified the evolution in indicators HIF-1α in children with anemia in CKD.  In parallel with a decrease GFR, the tightness of the connection between HIF-1α and GFR decreases.