ESPN 50th Annual Meeting

ESPN 2017


 
Significance of examination of concentration of IL-10 in 24 h urine for early diagnostic of renal scarring in patients with vesicoureteric reflux
IGOR ZORIN ALBINA VYALKOVA OXANA USTINOVA 2 LARISA GAJKOVA 2 ALEVTINA IZVEKOVA 2 ANNA LIFICHENKO 2 SVETLANA TCHESNOKOVA 1 SVETLANA DREBEZOVA 1 ELENA GUNKOVA 1

1- ORENBURG MEDICAL UNIVERSITY
2- CLINICAL PAEDIATRIC HOSPITAL 6
 
Introduction:

 The aim of the study was to determine concentration of IL-10 in urine of patients with vesicoureteric reflux (VUR) and reflux nephropathy A (RN A) for early diagnostic of renal scarring. 

Material and methods:

 We examined 60 children with RN A and VUR. All children were  comparable on gender and age. All patients underwent ultrasound, X-ray and DMSA scan. We examined concentration of IL-10 in 24 h urine of patients by ELISA. Children were divided into 2 groups:

I – with unilateral RN A according to classification of Smellie J. et all, 1975 (n=30);

II – with VUR without renal damage (n= 30)

Results:

 We established that data of concentration of IL-10 in 24 h urine of patients with VUR without renal damage was 19,23±0,32 pg/ml.  Concentration of IL-10 in 24 h urine of patients with unilateral RN A was 11,98±0,24 pg/ml. The ranges of concentration of IL-10 in 24 h urine of patients with VUR without renal damage were significant different with concentration of IL-10 in 24 h urine of patients with RN A (p<0,05). So, we determined that concentration of IL-10 in      24 h urine decreased in process of renal scarring.

Conclusions:

 Concentration of IL-10 in 24 h urine can be used for early diagnostic of renal scarring in children with VUR.