ESPN 50th Annual Meeting

ESPN 2017


 
CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT (CAKUT) IN THE ETIOLOGICAL STRUCTURE CHRONIC KIDNEY DISEASE (CKD) IN CHILDREN AND ADOLESCENTS
ELENA LYSOVA 1 NADEZHDA SAVENKOVA 1 IRINA KUTYRLO 1

1- SAINT-PETERSBURG STATE PEDIATRIC MEDICAL UNIVERSITY, RUSSIAN FEDERATION
 
Introduction:

To study the frequency CAKUT in the etiological structure CKD by children and adolescents.

Material and methods:

This study includes  80 children with CKD, 34 children of them had СAKUT  in age 9,4±5,4 years. Out of 34 children - 22 boys (64,4 %) and 12 girls (35,6%).

Results:

It is established that in the etiological structure of CKD in 80 children and adolescents is dominated by congenital and hereditary kidney diseases in 75 % cases. СAKUT was diagnosed in 24 (70,5%) patients in perinatal and infantile period. From  34 children with СAKUT: 18 patients (53%) had vesicoureteral reflux (VUR) (single or double direction) stage IV- V, 1 patient (3%) had bladder extrophy, 7 patients (20.5 %) had hydronephrosis stage III-IV, 8 patients (23.5%) had reflux-nephropathy. Patients with VUR had posteror urethral valve, bladder dysfunction, ureterohydronephrosis. Reflux-nephropathy stage C, D is manifested by proteinuria, hypertension, renal scarring. Urinary tract infectionhad 26 (76,4%) patients. Children with СAKUT  had eGFR 28,6 ±  22,3 ml/ min on 1,73 m2. Out of 34 children with CKD was diagnosted stage V in 11 (32,4%) patients,  stage IV in 13 (38,2%) patients, stage III in 3 (14,7%) patients,  stage II in 4 (11,5%) patients, stage I in 1 (2,9%) patients.

Conclusions:

It is established that in the etiological structure of in 80 children and adolescents with CKD dominated by congenital and hereditary kidney diseases (75%), among which prevails CAKUT (56,5 %).