ESPN 50th Annual Meeting

ESPN 2017


 
The role of family history, associated comorbidities and body mass index in predicting response to enuresis treatment
MATJAž KOPAč 1

1- UNIVERSITY MEDICAL CENTRE LJUBLJANA, DIVISION OF PEDIATRICS, DEPARTMENT OF NEPHROLOGY
 
Introduction:

 

The purpose of this study was to evaluate the role of family history of enuresis, associated comorbidities (mental disability, history of head trauma, allergies etc.) and body mass index (BMI) in predicting response to enuresis treatment.

Material and methods:

 

100 patients with monosymptomatic enuresis were evaluated in this retrospective study. The association between family history of enuresis, associated comorbidities, body mass index and response to enuresis treatment with desmopressin melt oral formulation were analysed with χ2 statistical test, using computer programme Microsoft Excel statistical tests.

Results:

Family history of enuresis was positive in 20 (58.8 %) among 34 patients who responded to desmopressin treatment and in 18 (54.5 %) patients among 33 non-responders. The difference was not statistically significant.

Among 42 patients who responded to desmopressin treatment, obesity was present in 6 (14.3 %), overweight in 8 (19 %) and normal weight in 28 (66.7 %) patients. Among 38 non-responders, obesity was present in 5 (13.2 %), overweight in 3 (7.9 %) and normal weight in 30 (78.9 %) patients. The difference was not statistically significant.

Among 42 patients who responded to desmopressin treatment, comorbidity was present in 17 patients (40.5 %). Among 38 non-responders, comorbidity was present in only 8 patients (21.1 %) but the difference did not reach statistical significance.

The group of patients treated with alarm consisted of 23 children which is not enough for a reliable statistical analysis.

All patients had normal urinalysis (5 had mild isolated microhematuria) and normal ultrasound of kidneys and urinary tract (not done in 4).

Conclusions:

 

The study did not prove statistically significant association between family history of enuresis, associated comorbidities or body mass index and response to enuresis treatment with desmopressin.