ESPN 50th Annual Meeting

ESPN 2017

Role of bioelectrical impedance analysis in nutritional evaluation of children on haemodialysis: a single centre study
Vasiliki Karava 1 Varvara Askiti 1 Maria Mila 1 Argyroula Zampetoglou 1 Andromach Mitsioni 1 Constantinos J. Stefanidis 1

1- Nephrology Department, "P. & A. Kyriakou" Children Hospital, Athens, Greece

This cohort aims to study the usefulness of bioelectrical impedance analysis (BIA) for body muscle mass assessment in children on haemodialysis (HD).

Material and methods:

We have undertaken a retrospective study from January 2013 to December 2016 on the results of lean tissue mass index (LTI) measured by bioelectrical impedance analysis (BIA) in all children aged ≥ 5 years old with HD duration ≥ 6 months. Annual average LTI, normalized protein catabolized rate (nPCR), body mass index (BMI), diuresis, haemoglobin and serum ferritin, albumin, bicarbonate, 25-hydroxyvitamin D levels were calculated for each child.


16 children (9 boys, 7 girls) aged from 5 to 17 years old were included. The median study period per child was 2 years (range 1-4). BMI z -score was <-1.5 in 6 patients. Total median LTI change of all patients was +5.07%. Total average LTI of each patient was not influenced by sex, age or diuresis status. A significant linear correlation was observed between BMI level and LTI and between BMI z-score and LTI (r=0.593, p<0.001 and r=0.673, p<0.001). We noticed that only 1 child presented a BMI z-score fall below -1.5  during the study period and was the only one who presented an LTI decrease more than 2%. A significant linear correlation was observed between nPCR level and LTI (r=0.35, p=0.031). Annual changes of nPCR level was related to those of LTI (Rho=0.465, p=0.029) and its annual positive or negative changes were related to similar LTI changes (p=0.075). 25-hydoxyvitamin D level was the only biochemical parameter significantly correlated with LTI (r=0.331, p=0.042).



Bioelectrical impedance analysis seems to be a valuable and reliable tool for body muscle mass assessment and follow-up in children on HD. 25-hydroxyvitamin D plays probably a beneficial role on body muscle mass.