ESPN 50th Annual Meeting

ESPN 2017


 
STEROID STARTED FOUR TUBULOINTERSTITIAL NEPHRITIS CASES
EMEL ISIYEL 1 UMUT SELDA BAYRAKCI 1 ADEM YASIN KOKSOY 1 FATMA SEMSA CAYCI 1 ASLI KANTAR OZSAHIN 1

1- ANKARA CHILD HEALTH AND DISEASES HEMATOLOGY ONCOLOGY TRAINING AND RESEARCH HOSPITAL, DEPARTMENT OF PEDIATRIC NEPHROLOGY
 
Introduction:

Tubulointerstitial nephritis (TIN) is associated with an immune-mediated infiltration of the kidney interstitium by inflammatory cells. Patients often present with nonspecific symptoms, which can lead to delayed diagnosis and treatment of the disease. The causes of acute TIN can be grouped into four broad categories: medications, infections, immunologic diseases or idiopathic processes.

Material and methods:

 We report four patients with increased creatinine and diagnosed with TIN after biopsy. 

Results:

CASE 1. A 16-year-old boy presented with a 1-month history of bilateral redness in the eyes and fever. He was diagnosed with uveitisLaboratory tests showed elevated creatinine levels; 1.7 mg/dL. Renal biopsy findings showed granulomatous interstitial inflammation and tubular atrophy.

CASE 2. A 14-year-girl presented with anorexia. Laboratory tests showed elevated creatinine levels; 1.85mg/dL. Her eye examination was normal. Renal biopsy findings showed interstitial inflammation and tubular atrophy.

CASE 3. A 15-year-boy presented with a 2-month history of bilateral redness in the eyes. He was diagnosed with uveitis. Laboratory tests showed elevated creatinine levels; 1.3 mg/dL.  Renal biopsy findings showed mild chronic parenchymal injury consisted with chronic TIN (interstitial fibrosis and tubular atrophy).

CASE 4. A 17-year-boy presented with bilateral side pain. In his medical history, he had upper respiratory tract infection 1 week ago. Laboratory tests showed elevated creatinine levels; 4 mg/dL. Renal biopsy findings showed interstitial inflammation and tubular atrophy.

Conclusions:

TIN should be considered in all patients with or without uveitis, hence steroids should be started to prevent chronic deterioration.