ESPN 50th Annual Meeting

ESPN 2017


 
Evaluation of wave pulse velocity in children and adolescents with chronic kidney disease
ANA PAULA BRECHERET 1 ANA LUCIA CARDOSO SANTOS ABREU 1 RENATA LOPES 1 ALUIZIO BARBOSA CARVALHO 1 FRANCISCO ANTONIO HELFENSTEIN FONSECA 1 MARIA CRISTINA ANDRADE 1

1- UNIVERSIDADE FEDERAL DE SÃO PAULO - UNIFESP
 
Introduction:

Cardiovascular disease remains the most common cause of mortality in chronic kidney disease (CKD). Arterial stiffening measured by wave pulse velocity (PWV) predicts cardiovascular events and mortality in adults. Defining arterial stiffness may help to determine the cardiovascular risk.

Objectives: Investigate wave pulse velocity among children and adolescents with CKD.

Material and methods:

In this cross-sectional study 57 patients (61.4% male), age 6.2-17.5 years, 44 with non-dialysis CKD and 13 on chronic dialysis were included in the analysis. The WPV was measured with an oscillometric device with inbuilt ARCSolver-algorithm (estimated by using the brachial waveform) and compared with previously established percentiles for PWV.

Results:

The prevalence of elevated WPV was 21.1%. In multivariate logistic regression, it was noted a higher risk of elevated WPV in patients on chronic dialysis when compared with non-dialysis CKD patients (PRadj=4.31, 95%CI:1.26-14.83, p=0.020). Hypertensive patients (stage 2) have a higher risk of elevated WPV when compared with normotensives (PRadj=3.11, 95%CI:1.17-8.24, p=0.022) as the patients younger than 12 years comparing with the older patients (PRadj=3.41, 95%CI:1.25-9.29, p=0.017).

Conclusions:

The findings suggest that lower ages, dialysis and hypertension in children and adolescents are independently associated with the increase of WPV. Further researches are needed to clarify these relations with cardiovascular complications in children and adolescents with CKD.