ESPN 50th Annual Meeting

ESPN 2017


 
Organ involvements in children with Henoch-Schonlein Purpura and affecting factors on kidney involvement
SAFAK DEMIRTAS 1 ISMAIL DURSUN 1 SEDA PINARBASI 1 ZUBEYDE GUNDUZ 1 HULYA AKGUN 2 HAKAN POYRAZOGLU 1 RUHAN DUSUNSEL 1

1- ERCIYES UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF PEDIATRIC NEPHROLOGY
2- ERCIYES UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF PATHOLOGY
 
Introduction:

IgA vaskulitis is the most common vasculitis seen in childhood. Though kidney involvement is a major factor affecting prognosis, every organ on body might be affected. The aim of this study is to determine the organ involvement and clinics, to identify the risk factors that increase the nephritis and to determine the long-term prognosis of patients with IgA vasculitis.

Material and methods:

415 IgA vasculitis patients who were followed in 1990 and 2016 in Erciyes University Pediatric Nephrology and Rheumatology Department were included into the study. Patients files were reviewed retrospectively. The patients presenting semptoms, organ involvement, treatment and long-term prognosis were determined.

Results:

In our study, 415 patients diagnosed with IgA vasculitis (HSP) were evaluated. Of the patients, 173 (41.7%) were female and 242 (58.3%) were male. The mean reference age was 8.3 ± 3.1 years. Skin involvement was found 100%, joint involvement was 77.1%, GIS involvement was 58.6%, renal involvement was 38.3%, scalp edema was 10.1%, scrotal involvement was 5.3% and central nervous system involvement was 1.6%. Pulmonary  involvement was detected in a child. One patient died from pulmonary involvement and one patient died  from infectiuos complication possibly due to Eculizumab. When risk factors for nephiritis were assessed, it was found that gastrointestinal involvement was more frequent in those with nephritis (p=0.01). Age, diastolic blood pressure and GIS involvement were correlated with renal involvement, and GIS involvement and diastolic blood pressure are found to be risk factors for renal involvement.

Conclusions:

 Age at diagnosis, elevated blood pressure and GIS involvement are important findings in predicting the development of nephritis in patients. Patients with GIS involvement should be carefully monitored for kidney involvement.