ESPN 50th Annual Meeting

ESPN 2017


 
Growth pattern of children with idiopathic nephrotic syndrome (INS): a study of 41 patients
NOUIR SALSABIL 1 MABROUK SAMEH 1 ELLAFI ZEINEB 1 AJMI HOUDA 1 TFIFHA MENIAR 1 CHEMLI JALEL 1 HASSAYOUN SAIDA 1 ZOUARI NOURA 1 ABROUG SAOUSSEN 1

1- UNIVERSITY HOSPITAL SAHLOUL
 
Introduction:

 Objective:

To evaluate the growth pattern in steroid responsive nephrotic syndrome (SRNS) Tunisian children

Material and methods:

We realized a retrospective analysis of the growth pattern of the children with SRNS followed in the department of pediatrics at the University hospital of sahloul (Sousse, Tunisia) during period of 16 years.

Results:

41 patients were included, 29 boys and 12 girls. The mean age at onset was 4.3 ± 2.3 years. According to patients initial response to steroids there were 16 cases of SRNS with infrequent relapses, 5 frequently relapsing SRNS and 20 cases of steroid dependent nephrotic syndrome. The threshold of steroid dependence was equal to 39 ± 20,6. mg/m²

The mean number of relapses was 4,3±4,06. The use of immunosuppressive medications was necessary in 14 cases (34.1%), after an average time of 36,28±31,35 months after the disease onset. A steroid sparing agent was introduced because of a slowing down in the growth speed in 5 cases.

At the beginning of follow up (first year), the mean height standard deviation (SD) was equal to 0,03 ± 1,38 SD, the growth speed was of 5,9 ± 3,2 cm/year. We noticed a slowing down from the 5th year of follow up, to end to a mean height SD equal to – 1,5±2,35 SD with a growth speed equal to 3,5±2,38 cm/year in the 10 th year. The mean follow up duration was 5.1± 3 years

Conclusions:

Growth impairment in SRNS is a severe complication that needs an early detection and an early use of steroid sparing agents.