ESPN 50th Annual Meeting

ESPN 2017

Chronic Kidney Disease in Neonates
SARA SHARIEF 3 Sherif El-Desoky 3 Khalid A kalhasan 1 Amr Albanna 2 Jameela Kari 3

1- Pediatrics Department, King Saud University, Riyadh, Kingdom of Saudi Arabia
2- King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Kingdom of Saudi Arabia
3- Faculty of Medicine, Paediatric Nephrology center of excellence, Department of Pediatrics, , King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

Chronic kidney disease (CKD) requiring renal replacement therapy (RRT) is rare in neonates. RRT in neonates is expensive, time consuming and difficult. Very little data about neonatal CKD is available from the developing countries

Material and methods:

 All neonates with evidence with CKD from 2005 to 2015 were reviewed. Follow up serum creatinine was recorded every six months


Total of 181 children presentedwith CKD. Their mean age at presentation was 11.1 days (95% CI 9.5-12.8) and the mean creatinine was 106.5 uml/l (95% CI 91.3-121.7).


Congenital anomalies of the kidneys and urinary tract (CAKUT) was the underlying cause in 84,5%. Mortality was high particularly in the first 6 months (10%) and reached 16% by 4 years of follow up. Younger age at presentation, male sex and hypertension were associated with higher mortality. On the last follow up 42 (41%) children had hypertension and 27 (26.5%) had significant proteinuria. Five children had received dialysis in the neonatal period and another 6 were started dialysis later on.


 Management of advanced CKD in neonates is challenging particularly in developing countries