ESPN 50th Annual Meeting

ESPN 2017


 
AN ASSOCIATION BETWEEN URINARY METABOLIC DISTURBANCES AND INFANT FEEDING IN CHILDREN WITH MALABSORPTION SYNDROME
ELENA TUSH 1 TATIANA LAZAREVA 1 OLGA KHALETSKAYA 1

1- NIZHGMA
 
Introduction:

Big affinity of functioning of plasmatic membranes of a kidney and bowel at transport of various elements, including oxalates and uric acid is noted. So, the aim of our study is investigate urinary metabolic disturbances at children with a malabsorption syndrome depending on character of food on the first year of life.

Material and methods:

 92 children with syndrome of malabsorption who are earlier not examined and not the treated concerning changes from an urinary system aged from 2 months up to 6 years have been examined. From them - 42 (45.6%) patients with a celiac disease, 50 (54.4%) - with chronic enteritis. 51 (65.2%) of the patient had clinical manifestation of the main disease, 41 (34.8%) had a phase of incomplete clinical laboratory remission. The daily excretion of oxalates, uric acid, creatinine was investigated, character of food on 1 year of life was analyzed.

Results:

Direct correlation between metabolic disturbances in relatives  and hyperoxaluria in the child is revealed (r=0.42; р=0.01).
It is received that  children early separated from a breast had incresed risk of hyperoxaluriya by 1.4 times (р =0.003). Children who separated from a breast up to 6 months had excretion of oxalates of urine 2.90±0.24 and after 6 months — 2.33±0.21 mg/kg/days. Children who received meat up to 6 months had a statistically significantly higher daily excretion of uric acid  (2.91±0.49 and 1.78±0.16 respectively, t = 2.605; p=0.01), and uric acid/creatinine and calcium/creatinine index too.

Conclusions:

Character of food on 1 year of life has significant effect on a functional condition of kidneys. The early end of the breastfeeding and start of a meat feeding up has adverse effect.