ESPN 50th Annual Meeting

ESPN 2017


 
Automated Estimated GFR reporting can reduce the need for measured GFR in oncology patients
ANDREW LUNN 1 Sophie Wilne 1

1- NOTTINGHAM CHILDRENS HOSPITAL
 
Introduction:

 Automated estimated glomerular filtration rate(eGFR) reporting is established adult practice and improves detection of chronic kidney disease (CKD). eGFR formula in children commonly require height which is not routinely available when measuring creatinine. We have previously assessed a height independent eGFR (Table 1) and are using this in clinical practice to automatically report eGFR. We reviewed our data to establish whether it could be used to identify patients who did not need a measured GFR (mGFR) in order to determine dosing of chemotherapy.

 

 

Material and methods:

Data from  patients who had been used to locally optimise and validate a height independant formula were assessed to determine cut-offs which would identify those with a mGFR > 60 ml/min per 1.73m2 and those with a mGFR > 80 ml/min per 1.73m2

Results:

 263 patients (56% male, mean age 9.4 years, range 5 months to 17.9 years) were included in our data analysis. 144 patients had an eGFR > 90 ml/min per 1.73mof whom 99.3% had a mGFR > 60 ml/min per 1.73m. 79 patients had an eGFR > 100 ml/min per 1.73m, all of whom had a mGFR > 80 ml/min per 1.73m2.

Conclusions:

Estimated GFR reporting can accurately identify children with a measured GFR greater than 60 ml/min per 1.73m and greater than 80ml/min per 1.73m. This could reduce the number of children requiring a measured GFR prior to being treated with some chemotherapy agents.