ESPN 50th Annual Meeting

ESPN 2017


 
Is NT-ProBNP a Reliable Marker for Body Fluid Status in Children with Chronic Kidney Disease?
HULYA NALCACIOGLU 1 OZAN OZKAYA 1 H.CANDAS KAFALI 2 DEMET TEKCAN 1 BAHATTIN AVCI 3 KEMAL BAYSAL 2

1- ONDOKUZ MAYIS UNIVERSITY FACULTY OF MEDICINE, PEDIATRIC NEPHROLOGY DEPARTMENT, SAMSUN, TURKEY
2- ONDOKUZ MAYIS UNIVERSITY FACULTY OF MEDICINE, PEDIATRIC CARDIOLOGY DEPARTMENT, SAMSUN, TURKEY
3- ONDOKUZ MAYIS UNIVERSITY FACULTY OF MEDICINE,BIOCHEMISTRY DEPARTMENT, SAMSUN, TURKEY
 
Introduction:

  The aim of the study was to evaluate the body fluid content with calculations of NT-proBNP and bioimpedance spectroscopy in children undergoing hemodialysis (HD) and peritoneal dialysis (PD), and in children with chronic kidney disease (CKD) with no need of renal replacement therapy, and to investigate the association between cardiovasculary changes and NT-proBNP. 

Material and methods:

 The study included 65 children: 10 pre-dialysis patients with CKD (mean age: 10.50 ± 2.27 years), 13 patients undergoing HD (mean age: 11.92 ± 3.13 years), 12 patients undergoing PD (mean age: 11.42 ± 3.18), and 30 healthy controls (mean age: 10.11 ± 3.74).

Results:

 There was no statistical difference between the groups considering age, sex, and body surface area (BSA). NT-proBNP levels of HD and PD patients were statistically higher compared with the control group (p<0.001, p<0.001), there was no difference between pre-dialysis patients and the control group. OH, Rel OH, E/I levels of HD and PD patients significantly increased compared with the pre-dialysis and control group. Left atrium diameter, early dialostic flow velocity/late diastolic flow velocity (E/A) in HD and PD patients, and left ventricle mass index in HD, PD and pre-dialysis patients were significantly higher compared with the control group. A positive correlation between NT-proBNP and OH, Rel OH, E/I, left atrium diameter, left ventricle mass index and a negative correlation with E/A was detected. 

Conclusions:

 NT-proBNP and body fluid load was found to be increased in dialysis patients  and these pararmeters were associated with left ventricle systolic and diastolic function parameters. Therefore, we believe that the routine use of NT-proBNP in children with chronic kidney failure has importance for close follow-up and prognosis of patients.