ESPN 50th Annual Meeting

ESPN 2017


 
Metabolic syndrome and left ventricular hypertrophy in children after renal transplantation
SEHA SAYGILI 1 NUR CANPOLAT 1 RÜMEYSA YASEMIN ÇIÇEK 1 SALIM ÇALIŞKAN 1 FATMA LALE SEVER 1

1- DEPARTMENT OF PEDIATRICS, DIVISION OF PEDIATRIC NEPHROLOGY, İSTANBUL UNIVERSITY CERRAHPAŞA FACULTY OF MEDICINE, İSTANBUL, TURKEY
 
Introduction:

 Whereas renal transplantation(RTx) reverses uremic abnormalities; additional risk factors for cardiovascular disease like hypertension, diabetes and metabolic syndrome (MS) may arise. The present study aims to evaluate the prevalence of MS in pediatric RTx recipients and the association of MS with left ventricular hypertrophy(LVH) as a risk factor for cardiovascular disease.

Material and methods:

A total of 36 RTx recipients (15 female, aged between 10 to 21 years) who were transplanted before 18 years of age were enrolled in the study. Anthropometric measurements were performed and their SD scores were calculated according to the national percentiles. Casual blood pressure (BP)s were measured and their z scores were calculated. Data on primary renal disease, modality and duration of dialysis, donor and transplant properties and certain laboratory findings were retrospectively documented from patient’s records. Left ventricular mass index (LVMI) was calculated from echocardiographic measurements, and LVH assessed for height-age. MS was defined by International Diabetes Federation (IDF) criteria.

Results:

 Ten out of 36 patients (28%) showed MS. Patients with MS had shorter transplant vintage compared with those without MS (25.9±14.9 vs 49.1±29.9 months, p=0.04); however there were no differences considering age, gender, weight gain after transplantation and other clinical data between the groups. Patients with MS had higher LVMI than the patients without MS (42.8±8.7 g/m2.7 vs 35.7±9.4 g/m2.7, p=0.044). The prevalence of LVH was 60% in the patients with MS, but 38.5% without MS (p=0.285). There was no correlation between LVMI and metabolic syndrome criteria including SD scores of waist circumference, z scores of systolic and diastolic BP, triglycerides and HDL levels the patients with MS and in the whole group.

Conclusions:

 Metabolic syndrome is a common condition in pediatric RTx recipients and associated with increased risk of LVH.