ESPN 50th Annual Meeting

ESPN 2017


 
IgA nephropathy in children: a single center experience
HARIKA ALPAY 1 ÜLGER ALTUNTAŞ 1 NURDAN YILDIZ 1 MEHTAP SAK 1 IBRAHİM GOKCE 1

1- MARMARA UNIVERSITY MEDICAL FACULTY
 
Introduction:

Immunoglobulin A nephropathy (IgAN) is the most common biopsy-proven primary glomerulonephritis in pediatric population. The clinical presentation of the disease in children varies from microscopic hematuria to end-stage kidney disease. The aim of this study was to evaluate the clinical features, treatments, and follow-up results of the children with IgAN. 

Material and methods:

 This is a retrospective study. Patients who had a histopathologically proven diagnosis of IgAN during the period of 2000-2017 were included in the study. 

Results:

 A total of 30 patients with IgAN were analyzed; 17 (56.7%) patients were male and 13 (43.3%) were female. The mean age at onset and admission (± standard deviation) of patients with IgAN was  123.53 ± 50.64 (range:31-237, median: 112.5) and 132.27 ± 50.32 (range:34-240, median: 129.5) months respectively. Kidney biopsy was performed approximately 16 ± 22.12 months after onset of the disease. The mean follow-up time  was 44.53 ± 38.81 (range:6-150, median: 34.5) months. Nineteen (63.3%) patients presented with recurrent macroscopic hematuria, five (16.7%) with microscopic hematuria ± proteinuria, five (16.7%) with nephritic syndrome, and one (3.3%) with proteinuria. IgA co-deposition with C3 (n:16, 53.3%) was the most common finding in the IF study. At present, 17 (56.7%) patients have minor urinary abnormalities, three (10%) have active renal disease while 10 (33.3%) patients are followed with normal renal and urinary findings. None of the patients developed renal failure. Hypertension was present in only 2 (6.7%) patients.

Conclusions:

 The majority of children with IgAN in this study were admitted with recurrent macroscopic hematuria and most of them had a good prognosis. We think that favorable prognosis may be possible with early diagnosis of IgAN in children.