ESPN 50th Annual Meeting

ESPN 2017


 
Polyomavirus BK Infection in Pediatric Renal Transplant Patients
BEGÜM AVCI 1 ESRA BASKIN 1 KAAN GÜLLEROĞLU 1 ÖZLEM KAZANCI 1 HANDAN ÖZDEMIR 2 GÖKHAN MORAY 3 MEHMET HABERAL 3

1- PEDIATRIC NEPHROLOGY, BASKENT UNIVERSITY, ANKARA, TURKEY
2- PATHOLOGY, BASKENT UNIVERSITY, ANKARA, TURKEY
3- GENERAL SURGERY, BASKENT UNIVERSITY, ANKARA, TURKEY
 
Introduction:

 Polyomavirus BK (BKV) is a common infections and an  important cause of graft loss. The purpose of this study was to determine the incidence, clinical features and risk factors of BKV infection in pediatric renal transplant patients  in our center.

Material and methods:

 We retrospectively scanned the data files of 122 patients who had renal transplant.  BKV values were recorded measured by quantitative polymerase chain reaction test in urine and serum. Patients with and without Polyoma BK infection were compared to assess risk factors in terms of chronic renal failure etiology, donor types, immunosuppressive treatments, ureteral stent, acute rejection episodes and accompanying viral infection. 

Results:

 BKV infection were detected in 10 patients (8,19%). Ten patients (100%) developed BKV viruri; 7 (70%) BKV viremia; 4 (40%) BKV nephropathy. Acute humoral rejection was present in 3 of BKV nephropathy. Graft loss developed in 2 (1.6%) patients with BKV nephropathy. Patients with BKV infection gender, age of transplantation, donor type, etiology of renal failure, immunosuppressive treatment, ureteral stent, acute rejection were similar to patients without BKV infection. There was no significant difference between first year GFR of patients with BKV infection and those without BKV infection. Accompanying CMV infection were significantly higher in patients with BKV infection (p = 0.013). BK virus nephropathy had more acute rejection, ureteral stent, CMV association and higher rate of graft loss than BK viruri or viremia (p<0,01).

Conclusions:

The risk of developing graft loss is high in patients with BKV nephropathy. Close monitoring, early detection have a significant effect on the prognosis of polyomavirus BK infection.