ESPN 50th Annual Meeting

ESPN 2017


 
Is urine intercellular adhesion molecule-1 a marker of renal disorder in children with ureteropelvic junction obstruction?
KATARZYNA TARANTA-JANUSZ 1 JOANNA MICHALUK-SKUTNIK 1 ANNA WASILEWSKA 1

1- DEPARTMENT OF PEDIATRICS AND NEPHROLOGY, MEDICAL UNIVERSITY OF BIALYSTOK
 
Introduction:

 Hydronephrosis (HN) is a common pathology in pediatric nephrology. Ureteropelvic junction obstruction (UPJO) is the most common cause of severe hydronephrosis in children.

The evolution of obstructive nephropathy can be envisioned as an overlapping sequence of cellular events, including tubular dilatation, interstitial inflammation, followed by glomerulotubular injury and progressive interstitial fibrosis. Inflammation is mediated by the up-regulation of chemokines, adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1), monocyte chemotactic protein-1, and osteopontin.

We aimed to investigate whether urine intercellular adhesion molecule-1 (ICAM-1) might serve as a marker of renal disorder in children with hydronephrosis caused by ureteropelvic junction obstruction.

Material and methods:

 29 children with severe HN (M- 23; F- 6; mean age 3.8 ± 5.02 years) were compared with 23 participants with mild HN (mean age 6.29 ± 5.04 yrs) and with 19 (mean age 5.28 ± 4.25 yrs) healthy peers age- and sex-matched. ICAM-1 was measured in urine using ELISA method, and was expressed as ng/ mg Cre.

Results:

 Urine ICAM-1/ uCre levels were significantly higher in HN children than healthy controls (P <0.01), and in severe HN when compared to mild HN (P <0.05). A negative correlation between uICAM-1/ uCre and DRF was found in all studied children (r= -0.5, P <0.05).

Conclusions:

 Present study showed significantly higher uICAM-1/ uCre levels in children with severe HN than with mild HN. Larger studies are invited to confirm the clinical usefulness of ICAM-1 as biomarker in the diagnosis and follow-up of children with obstructive nephropathy. It seemed to us that uICAM-1 could be a good marker of renal disorder, and might have the potential to predict which patients will require surgery.